CATH Domain 5f0gA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
	1.20.1050.10

Domain Context

CATH Clusters

Superfamily	1.20.1050.10
Functional Family	Glutathione S-transferase 1-1

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt Q9VG98

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

UniProtKB Entries (1)

Q9VG98

GSTD2_DROME

Drosophila melanogaster

Glutathione S-transferase D2

PDB Structure

PDB	5F0G
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of a Drosophila glutathione transferase involved in isothiocyanate detoxification. Gonzalez, D., Fraichard, S., Grassein, P., Delarue, P., Senet, P., Nicolai, A., Chavanne, E., Mucher, E., Artur, Y., Ferveur, J.F., Heydel, J.M., Briand, L., Neiers, F. Insect Biochem. Mol. Biol.