CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.200 | Phosphorylase Kinase; domain 1 | |
3.30.200.20 | Phosphorylase Kinase; domain 1 |
Domain Context
CATH Clusters
Superfamily | Phosphorylase Kinase; domain 1 |
Functional Family | Dual specificity mitogen-activated protein kinase kinase 1 |
Enzyme Information
2.7.12.2 |
Mitogen-activated protein kinase kinase.
based on mapping to UniProt Q02750
ATP + a protein = ADP + a phosphoprotein.
-!- A dual-specific protein kinase and requires mitogen-activated protein kinase kinase kinase (MAPKKK) for activation. -!- It is required for activation of EC 2.7.11.24. -!- Phosphorylation of MEK1 by Raf involves phosphorylation of two serine residues. -!- Mitogen-activated protein kinase (MAPK) signal transduction pathways are among the most widespread mechanisms of cellular regulation. -!- Mammalian MAPK pathways can be recruited by a wide variety of stimuli including hormones (e.g. insulin and growth hormone), mitogens (e.g. epidermal growth factor and platelet-derived growth factor), vasoactive peptides (e.g. angiotensin-II and endothelin), inflammatory cytokines of the tumor necrosis factor (TNF) family and environmental stresses such as osmotic shock, ionizing radiation and ischemeic injury.
|
UniProtKB Entries (1)
Q02750 |
MP2K1_HUMAN
Homo sapiens
Dual specificity mitogen-activated protein kinase kinase 1
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PDB Structure
PDB | 5EYM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases.
Mol.Cancer Ther.
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