CATH Domain 5eqeA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Choline kinase alpha

Enzyme Information

2.7.1.82	Ethanolamine kinase. based on mapping to UniProt P35790 ATP + ethanolamine = ADP + O-phosphoethanolamine.
2.7.1.32	Choline kinase. based on mapping to UniProt P35790 ATP + choline = ADP + phosphocholine. -!- Ethanolamine and its methyl and ethyl derivatives can also act as acceptors.

UniProtKB Entries (1)

CHKA_HUMAN

Homo sapiens

Choline kinase alpha

PDB Structure

PDB	5EQE
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Novel Small Molecule Inhibitors of Choline Kinase Identified by Fragment-Based Drug Discovery. Zech, S.G., Kohlmann, A., Zhou, T., Li, F., Squillace, R.M., Parillon, L.E., Greenfield, M.T., Miller, D.P., Qi, J., Thomas, R.M., Wang, Y., Xu, Y., Miret, J.J., Shakespeare, W.C., Zhu, X., Dalgarno, D.C. J.Med.Chem.