CATH Domain 5eppA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.10	Roll
	3.10.330	Vcp-like ATPase; Chain A, domain 2
	3.10.330.10

Domain Context

CATH Clusters

Superfamily	3.10.330.10
Functional Family	Cell division control 48

Enzyme Information

3.6.4.6

Vesicle-fusing ATPase.

based on mapping to UniProt P55072

ATP + H(2)O = ADP + phosphate.

-!- A large family of ATP-hydrolyzing enzymes involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments. -!- They belong to the AAA-type (ATPase associated with a variety of cell activities) ATPase superfamily. -!- They include peroxin, which apparently is involved in Zellweger's syndrome.

UniProtKB Entries (1)

Q8TEB9

RHBL4_HUMAN

Homo sapiens

Rhomboid-related protein 4

PDB Structure

PDB	5EPP
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insights into the interaction of p97 N-terminus domain and VBM in rhomboid protease, RHBDL4. Lim, J.J., Lee, Y., Ly, T.T., Kang, J.Y., Lee, J.G., An, J.Y., Youn, H.S., Park, K.R., Kim, T.G., Yang, J.K., Jun, Y., Eom, S.H. Biochem.J.