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1 keywords

CATH Domain 5ennA03

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.1070 Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, Domain 5
Homologous Superfamily 1.10.1070.11 Phosphatidylinositol 3-/4-kinase, catalytic domain

Domain Context

CATH Clusters

Superfamily Phosphatidylinositol 3-/4-kinase, catalytic domain
Functional Family Phosphatidylinositol 3-kinase catalytic subunit type 3

Enzyme Information

2.7.1.137
Phosphatidylinositol 3-kinase.
based on mapping to UniProt Q8NEB9
ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo- inositol 3-phosphate.

UniProtKB Entries (1)

Q8NEB9
PK3C3_HUMAN
Homo sapiens
Phosphatidylinositol 3-kinase catalytic subunit type 3

PDB Structure

PDB 5ENN
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Potent, selective, and orally bioavailable inhibitors of VPS34 provide chemical tools to modulate autophagy in vivo
Kearney, E.P.
To Be Published
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