CATH Domain 5ehrA01

Superfamily	SH2 domain
Functional Family	Tyrosine-protein phosphatase non-receptor type

3.1.3.48

Protein-tyrosine-phosphatase.

based on mapping to UniProt Q06124

Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.

PTN11_HUMAN

Homo sapiens

Tyrosine-protein phosphatase non-receptor type 11

PDB	5EHR
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Chen, Y.P., LaMarche, M.J., Chan, H.M., Fekkes, P., Garcia-Fortanet, J., Acker, M.G., Antonakos, B., Chen, C.H., Chen, Z., Cooke, V.G., Dobson, J.R., Deng, Z., Fei, F., Firestone, B., Fodor, M., Fridrich, C., Gao, H., Grunenfelder, D., Hao, H.X., Jacob, J., Ho, S., Hsiao, K., Kang, Z.B., Karki, R., Kato, M., Larrow, J., La Bonte, L.R., Lenoir, F., Liu, G., Liu, S., Majumdar, D., Meyer, M.J., Palermo, M., Perez, L., Pu, M., Price, E., Quinn, C., Shakya, S., Shultz, M.D., Slisz, J., Venkatesan, K., Wang, P., Warmuth, M., Williams, S., Yang, G., Yuan, J., Zhang, J.H., Zhu, P., Ramsey, T., Keen, N.J., Sellers, W.R., Stams, T., Fortin, P.D. Nature