CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.190 | Protein-Tyrosine Phosphatase; Chain A |
|
3.90.190.10 | Protein tyrosine phosphatase superfamily |
Domain Context
CATH Clusters
| Superfamily | Protein tyrosine phosphatase superfamily |
| Functional Family | Tyrosine-protein phosphatase non-receptor type |
Enzyme Information
| 3.1.3.48 |
Protein-tyrosine-phosphatase.
based on mapping to UniProt Q06124
Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.
-!- Dephosphorylates O-phosphotyrosine groups in phosphoproteins, such as the products of EC 2.7.10.2.
|
UniProtKB Entries (1)
| Q06124 |
PTN11_HUMAN
Homo sapiens
Tyrosine-protein phosphatase non-receptor type 11
|
PDB Structure
| PDB | 5EHP |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.
J.Med.Chem.
|
