CATH Domain 5eegA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.150	Vaccinia Virus protein VP39

Domain Context

CATH Clusters

Superfamily	Vaccinia Virus protein VP39
Functional Family	Carminomycin 4-O-methyltransferase DnrK

Enzyme Information

2.1.1.292

Carminomycin 4-O-methyltransferase.

based on mapping to UniProt Q06528

S-adenosyl-L-methionine + carminomycin = S-adenosyl-L-homocysteine + daunorubicin.

-!- The enzymes from the Gram-positive bacteria Streptomyces sp. C5 and Streptomyces peucetius are involved in the biosynthesis of the anthracycline daunorubicin. -!- In vitro the enzyme from Streptomyces sp. C5 also catalyzes the 4-O- methylation of 13-dihydrocarminomycin, rhodomycin D and 10-carboxy- 13-deoxycarminomycin.

UniProtKB Entries (1)

Q06528

DNRK_STRPE

Streptomyces peucetius

Carminomycin 4-O-methyltransferase DnrK

PDB Structure

PDB	5EEG
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Functional AdoMet Isosteres Resistant to Classical AdoMet Degradation Pathways. Huber, T.D., Wang, F., Singh, S., Johnson, B.R., Zhang, J., Sunkara, M., Van Lanen, S.G., Morris, A.J., Phillips, G.N., Thorson, J.S. Acs Chem.Biol.