CATH Domain 5edtA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.630	Cytochrome p450
	1.10.630.10	Cytochrome P450

Domain Context

CATH Clusters

Superfamily	Cytochrome P450
Functional Family	Mycocyclosin synthase

Enzyme Information

1.14.19.70

Mycocyclosin synthase.

based on mapping to UniProt P0A515

Cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H(+) + O(2) = mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + 2 H(2)O.

-!- A cytochrome P450 (heme-thiolate) protein from the bacterium Mycobacterium tuberculosis catalyzing an oxidative reaction that does not incorporate oxygen into the product. -!- Formerly EC 1.14.21.9.

1.14.-.-

Acting on paired donors, with incorporation or reduction of molecular oxygen. The oxygen incorporated need not be derived from O(2).

based on mapping to UniProt P0A515

UniProtKB Entries (1)

P0A515

CP121_MYCBO

Mycobacterium tuberculosis variant bovis AF2122/97

Cytochrome P450 121

PDB Structure

PDB	5EDT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors. Kavanagh, M.E., Coyne, A.G., McLean, K.J., James, G.G., Levy, C.W., Marino, L.B., de Carvalho, L.P., Chan, D.S., Hudson, S.A., Surade, S., Leys, D., Munro, A.W., Abell, C. J.Med.Chem.