CATH Domain 5eamA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.130	7 Propeller
	2.130.10	Methylamine Dehydrogenase; Chain H
	2.130.10.10	YVTN repeat-like/Quinoprotein amine dehydrogenase

Domain Context

CATH Clusters

Superfamily	YVTN repeat-like/Quinoprotein amine dehydrogenase
Functional Family	WD repeat-containing protein 5

Enzyme Information

UniProtKB Entries (1)

WDR5_HUMAN

Homo sapiens

WD repeat-containing protein 5

PDB Structure

PDB	5EAM
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1). Getlik, M., Smil, D., Zepeda-Velazquez, C., Bolshan, Y., Poda, G., Wu, H., Dong, A., Kuznetsova, E., Marcellus, R., Senisterra, G., Dombrovski, L., Hajian, T., Kiyota, T., Schapira, M., Arrowsmith, C.H., Brown, P.J., Vedadi, M., Al-Awar, R. J. Med. Chem.