CATH Domain 5ea9A02

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.30	Roll
	2.30.26	Dihydroorotate Dehydrogenase A; chain A, domain 2
	2.30.26.10	Dihydroorotate Dehydrogenase A, chain A, domain 2

Domain Context

CATH Clusters

Superfamily	Dihydroorotate Dehydrogenase A, chain A, domain 2
Functional Family	Dihydroorotate dehydrogenase (fumarate)

Enzyme Information

1.3.98.1

Dihydroorotate oxidase (fumarate).

based on mapping to UniProt Q4D3W2

(S)-dihydroorotate + fumarate = orotate + succinate.

-!- The reaction, which takes place in the cytosol, is the only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. -!- Molecular oxygen can replace fumarate in vitro. -!- Other class 1 dihydroorotate dehydrogenases use either NAD(+) (EC 1.3.1.14) or NADP(+) (EC 1.3.1.15) as electron acceptor. -!- The membrane bound class 2 dihydroorotate dehydrogenase (EC 1.3.5.2) uses quinone as electron acceptor. -!- Formerly EC 1.3.3.1.

UniProtKB Entries (1)

Q4D3W2

PYRD_TRYCC

Trypanosoma cruzi strain CL Brener

Dihydroorotate dehydrogenase (fumarate)

PDB Structure

PDB	5EA9
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Exploring Trypanosoma cruzi Dihydroorotate Dehydrogenase Active Site Plasticity for the Discovery of Potent and Selective Inhibitors with Trypanocidal Activity Rocha, J.R., Cheleski, J., Inaoka, D.K., Avelar, L.A., Ribeiro, J.F.R., Wiggers, H.J., Albuquerque, S., Shiba, T., Harada, S., Kita, K., Silva, A.B.F., Montanari, C.A. To be Published