CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphorylase Kinase; domain 1
Functional Family TGF-beta receptor type-2

Enzyme Information

2.7.11.30
Receptor protein serine/threonine kinase.
based on mapping to UniProt P37173
ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
-!- The transforming growth factor beta (TGF-beta) family of cytokines regulates cell proliferation, differentiation, recognition and death. -!- Signaling occurs by the binding of ligand to the type II receptor, which is the constitutively active kinase. -!- Bound TGF-beta is then recognized by receptor I, which is phosphorylated and can propagate the signal to downstream substrates. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P37173
TGFR2_HUMAN
Homo sapiens
TGF-beta receptor type-2

PDB Structure

PDB 5E8V
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structures of apo and inhibitor-bound TGF beta R2 kinase domain: insights into TGF beta R isoform selectivity.
Tebben, A.J., Ruzanov, M., Gao, M., Xie, D., Kiefer, S.E., Yan, C., Newitt, J.A., Zhang, L., Kim, K., Lu, H., Kopcho, L.M., Sheriff, S.
Acta Crystallogr D Struct Biol