CATH Domain 5dtwA00

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
	3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1

Superfamily	2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family	Probable enoyl-CoA hydratase echA6

4.2.1.17

Enoyl-CoA hydratase.

based on mapping to UniProt P9WNP1

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.

-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

ECHA6_MYCTU

Mycobacterium tuberculosis H37Rv

Probable enoyl-CoA hydratase echA6

PDB	5DTW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	THPP target assignment reveals EchA6 as an essential fatty acid shuttle in mycobacteria. Cox, J.A., Abrahams, K.A., Alemparte, C., Ghidelli-Disse, S., Rullas, J., Angulo-Barturen, I., Singh, A., Gurcha, S.S., Nataraj, V., Bethell, S., Remuinan, M.J., Encinas, L., Jervis, P.J., Cammack, N.C., Bhatt, A., Kruse, U., Bantscheff, M., Futterer, K., Barros, D., Ballell, L., Drewes, G., Besra, G.S. Nat Microbiol