CATH Domain 5drbA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.510	Transferase(Phosphotransferase); domain 1
	1.10.510.10	Transferase(Phosphotransferase) domain 1

Domain Context

CATH Clusters

Superfamily	Transferase(Phosphotransferase) domain 1
Functional Family	Serine/threonine-protein kinase WNK1 isoform 2

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q9JIH7

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q9JIH7

WNK1_RAT

Rattus norvegicus

Serine/threonine-protein kinase WNK1

PDB Structure

PDB	5DRB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Small-molecule WNK inhibition regulates cardiovascular and renal function. Yamada, K., Park, H.M., Rigel, D.F., DiPetrillo, K., Whalen, E.J., Anisowicz, A., Beil, M., Berstler, J., Brocklehurst, C.E., Burdick, D.A., Caplan, S.L., Capparelli, M.P., Chen, G., Chen, W., Dale, B., Deng, L., Fu, F., Hamamatsu, N., Harasaki, K., Herr, T., Hoffmann, P., Hu, Q.Y., Huang, W.J., Idamakanti, N., Imase, H., Iwaki, Y., Jain, M., Jeyaseelan, J., Kato, M., Kaushik, V.K., Kohls, D., Kunjathoor, V., LaSala, D., Lee, J., Liu, J., Luo, Y., Ma, F., Mo, R., Mowbray, S., Mogi, M., Ossola, F., Pandey, P., Patel, S.J., Raghavan, S., Salem, B., Shanado, Y.H., Trakshel, G.M., Turner, G., Wakai, H., Wang, C., Weldon, S., Wielicki, J.B., Xie, X., Xu, L., Yagi, Y.I., Yasoshima, K., Yin, J., Yowe, D., Zhang, J.H., Zheng, G., Monovich, L. Nat.Chem.Biol.