CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family Iridoid synthase

Enzyme Information

1.3.1.99
Iridoid synthase.
based on mapping to UniProt K7WDL7
(6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+).
-!- Isolated from the plant Catharanthus roseus. -!- The reaction may involve cyclization via a Diels-Alder or Michael reaction. -!- Iridoids are involved in the biosynthesis of many indole alkaloids. -!- The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.

UniProtKB Entries (1)

K7WDL7
IRIS_CATRO
Catharanthus roseus
Iridoid synthase

PDB Structure

PDB 5DF1
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
Kries, H., Caputi, L., Stevenson, C.E., Kamileen, M.O., Sherden, N.H., Geu-Flores, F., Lawson, D.M., O'Connor, S.E.
Nat.Chem.Biol.