CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
Superfamily | NAD(P)-binding Rossmann-like Domain |
Functional Family | Iridoid synthase |
Enzyme Information
1.3.1.99 |
Iridoid synthase.
based on mapping to UniProt K7WDL7
(6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+).
-!- Isolated from the plant Catharanthus roseus. -!- The reaction may involve cyclization via a Diels-Alder or Michael reaction. -!- Iridoids are involved in the biosynthesis of many indole alkaloids. -!- The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.
|
UniProtKB Entries (1)
K7WDL7 |
IRIS_CATRO
Catharanthus roseus
Iridoid synthase
|
PDB Structure
PDB | 5DF1 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural determinants of reductive terpene cyclization in iridoid biosynthesis.
Nat.Chem.Biol.
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