CATH Domain 5deyA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	Non-specific serine/threonine protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt Q13153

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

Q13153

PAK1_HUMAN

Homo sapiens

Serine/threonine-protein kinase PAK 1

PDB Structure

PDB	5DEY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety. Ndubaku, C.O., Crawford, J.J., Drobnick, J., Aliagas, I., Campbell, D., Dong, P., Dornan, L.M., Duron, S., Epler, J., Gazzard, L., Heise, C.E., Hoeflich, K.P., Jakubiak, D., La, H., Lee, W., Lin, B., Lyssikatos, J.P., Maksimoska, J., Marmorstein, R., Murray, L.J., O'Brien, T., Oh, A., Ramaswamy, S., Wang, W., Zhao, X., Zhong, Y., Blackwood, E., Rudolph, J. Acs Med.Chem.Lett.