CATH Domain 5de1A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.718	Isopropylmalate Dehydrogenase
	3.40.718.10	Isopropylmalate Dehydrogenase

Domain Context

CATH Clusters

Superfamily	Isopropylmalate Dehydrogenase
Functional Family	Isocitrate dehydrogenase [NADP]

Enzyme Information

1.1.1.42

Isocitrate dehydrogenase (NADP(+)).

based on mapping to UniProt O75874

Isocitrate + NADP(+) = 2-oxoglutarate + CO(2) + NADPH.

-!- Unlike EC 1.1.1.41, oxalosuccinate can be used as a substrate. -!- In eukaryotes, isocitrate dehydrogenase exists in two forms: an NAD(+)-linked enzyme found only in mitochondria and displaying allosteric properties, and a non-allosteric, NADP(+)-linked enzyme that is found in both mitochondria and cytoplasm. -!- The enzyme from some species can also use NAD(+) but much more slowly.

UniProtKB Entries (1)

O75874

IDHC_HUMAN

Homo sapiens

Isocitrate dehydrogenase [NADP] cytoplasmic

PDB Structure

PDB	5DE1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Okoye-Okafor, U.C., Bartholdy, B., Cartier, J., Gao, E.N., Pietrak, B., Rendina, A.R., Rominger, C., Quinn, C., Smallwood, A., Wiggall, K.J., Reif, A.J., Schmidt, S.J., Qi, H., Zhao, H., Joberty, G., Faelth-Savitski, M., Bantscheff, M., Drewes, G., Duraiswami, C., Brady, P., Groy, A., Narayanagari, S.R., Antony-Debre, I., Mitchell, K., Wang, H.R., Kao, Y.R., Christopeit, M., Carvajal, L., Barreyro, L., Paietta, E., Makishima, H., Will, B., Concha, N., Adams, N.D., Schwartz, B., McCabe, M.T., Maciejewski, J., Verma, A., Steidl, U. Nat.Chem.Biol.