CATH Domain 5dcwA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Iridoid synthase

Enzyme Information

1.3.1.99

Iridoid synthase.

based on mapping to UniProt K7WDL7

(6E)-8-oxogeranial + NAD(P)H = cis-trans-nepetalactol + NAD(P)(+).

-!- Isolated from the plant Catharanthus roseus. -!- The reaction may involve cyclization via a Diels-Alder or Michael reaction. -!- Iridoids are involved in the biosynthesis of many indole alkaloids. -!- The cyclic hemiacetal is readily hydrolyzed to the corresponding dial.

UniProtKB Entries (1)

K7WDL7

IRIS_CATRO

Catharanthus roseus

Iridoid synthase

PDB Structure

PDB	5DCW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Kries, H., Caputi, L., Stevenson, C.E., Kamileen, M.O., Sherden, N.H., Geu-Flores, F., Lawson, D.M., O'Connor, S.E. Nat.Chem.Biol.