CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.30 | Roll |
|
2.30.30 | SH3 type barrels. |
|
2.30.30.10 | Integrase, C-terminal domain superfamily, retroviral |
Domain Context
CATH Clusters
| Superfamily | Integrase, C-terminal domain superfamily, retroviral |
| Functional Family |
Enzyme Information
| 3.6.1.23 |
dUTP diphosphatase.
based on mapping to UniProt P03365
dUTP + H(2)O = dUMP + diphosphate.
|
| 2.7.7.- |
Nucleotidyltransferases.
based on mapping to UniProt P03365
|
| 3.1.-.- |
Acting on ester bonds.
based on mapping to UniProt P03365
|
| 3.4.23.- |
Aspartic endopeptidases.
based on mapping to UniProt P03365
|
| 3.1.26.4 |
Ribonuclease H.
based on mapping to UniProt P03365
Endonucleolytic cleavage to 5'-phosphomonoester.
-!- Acts on RNA-DNA hybrids.
|
| 2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P03365
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
|
| 2.7.7.49 |
RNA-directed DNA polymerase.
based on mapping to UniProt P03365
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes RNA-template-directed extension of the 3'-end of a DNA strand by one deoxynucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a RNA or DNA primer. -!- DNA can also serve as template. -!- See also EC 2.7.7.7.
|
UniProtKB Entries (1)
| P03365 |
POL_MMTVB
Mouse mammary tumor virus (STRAIN BR6)
Gag-Pro-Pol polyprotein
|
PDB Structure
| PDB | 5D7U |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Cryo-EM reveals a novel octameric integrase structure for betaretroviral intasome function.
Nature
|
