CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.50 | Rossmann fold | |
3.40.50.150 | Vaccinia Virus protein VP39 |
Domain Context
CATH Clusters
Superfamily | Vaccinia Virus protein VP39 |
Functional Family |
Enzyme Information
2.1.1.244 |
Protein N-terminal methyltransferase.
based on mapping to UniProt Q9BV86
(1) 3 S-adenosyl-L-methionine + N-terminal-(A,S)PK-[protein] = 3 S-adenosyl-L-homocysteine + N-terminal-N,N,N-trimethyl-N- (A,S)PK-[protein]. (2) 2 S-adenosyl-L-methionine + N-terminal-PPK-[protein] = 2 S-adenosyl- L-homocysteine + N-terminal-N,N-dimethyl-N-PPK-[protein].
-!- This enzyme methylates the N-terminus of target proteins containing the N-terminal motif (Ala/Pro/Ser)-Pro-Lys after the initiator L-methionine is cleaved. -!- When the terminal amino acid is L-proline, the enzyme catalyzes two successive methylations of its alpha-amino group. -!- When the first amino acid is either L-alanine or L-serine, the enzyme catalyzes three successive methylations. -!- The Pro-Lys in positions 2-3 cannot be exchanged for other amino acids. -!- Formerly EC 2.1.1.n5.
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UniProtKB Entries (2)
Q9BV86 |
NTM1A_HUMAN
Homo sapiens
N-terminal Xaa-Pro-Lys N-methyltransferase 1
|
P02283 |
H2B_DROME
Drosophila melanogaster
Histone H2B
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PDB Structure
PDB | 5CVE |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Molecular basis for histone N-terminal methylation by NRMT1
Genes Dev.
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