CATH Domain 5cfdB00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.20

Domain Context

CATH Clusters

Superfamily	2.60.120.20
Functional Family	Genome polyprotein

Enzyme Information

2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt C0MHL9 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.6.4.13	RNA helicase. based on mapping to UniProt C0MHL9 ATP + H(2)O = ADP + phosphate. -!- RNA helicases utilize the energy from ATP hydrolysis to unwind RNA. -!- Some of them unwind RNA with a 3' to 5' polarity, other show 5' to 3' polarity. -!- Some helicases unwind DNA as well as RNA. -!- May be identical with EC 3.6.4.12 (DNA helicase).
3.4.22.28	Picornain 3C. based on mapping to UniProt C0MHL9 Selective cleavage of Gln-\|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly. -!- From entero-, rhino-, aphto- and cardioviruses. -!- Larger than the homologous virus picornain 2A. -!- Belongs to peptidase family C3.

UniProtKB Entries (1)

POLG_SAFV

Saffold virus

Genome polyprotein

PDB Structure

PDB	5CFD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure and Genome Release Mechanism of the Human Cardiovirus Saffold Virus 3. Mullapudi, E., Novacek, J., Palkova, L., Kulich, P., Lindberg, A.M., van Kuppeveld, F.J., Plevka, P. J.Virol.