CATH Domain 5ceiA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family

Enzyme Information

2.7.11.23

[RNA-polymerase]-subunit kinase.

based on mapping to UniProt P49336

ATP + [DNA-directed RNA polymerase] = ADP + [DNA-directed RNA polymerase] phosphate.

-!- Appears to be distinct from other protein phosphokinases. -!- Brings about multiple phosphorylation of the unique C-terminal repeat domain of the largest subunit of eukaryotic EC 2.7.7.6. -!- Does not phosphorylate casein, phosvitin or histone. -!- Formerly EC 2.7.1.141.

2.7.11.22

Cyclin-dependent kinase.

based on mapping to UniProt P49336

ATP + a protein = ADP + a phosphoprotein.

-!- Activation of cyclin-dependent kinases requires association of the enzyme with a regulatory subunit referred to as a cyclin. -!- It is the sequential activation and inactivation of cyclin-dependent kinases, through the periodic synthesis and destruction of cyclins, that provides the primary means of cell-cycle regulation. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

P24863

CCNC_HUMAN

Homo sapiens

Cyclin-C

PDB Structure

PDB	5CEI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Development of a Potent, Specific CDK8 Kinase Inhibitor Which Phenocopies CDK8/19 Knockout Cells. Koehler, M.F., Bergeron, P., Blackwood, E.M., Bowman, K., Clark, K.R., Firestein, R., Kiefer, J.R., Maskos, K., McCleland, M.L., Orren, L., Salphati, L., Schmidt, S., Schneider, E.V., Wu, J., Beresini, M.H. Acs Med.Chem.Lett.