CATH Domain 5cehA01

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.650	Cupin

Domain Context

CATH Clusters

Superfamily	Cupin
Functional Family	Putative lysine-specific demethylase 5b

Enzyme Information

1.14.11.-

With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors.

based on mapping to UniProt P29375

UniProtKB Entries (1)

KDM5A_HUMAN

Homo sapiens

Lysine-specific demethylase 5A

PDB Structure

PDB	5CEH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells. Vinogradova, M., Gehling, V.S., Gustafson, A., Arora, S., Tindell, C.A., Wilson, C., Williamson, K.E., Guler, G.D., Gangurde, P., Manieri, W., Busby, J., Flynn, E.M., Lan, F., Kim, H.J., Odate, S., Cochran, A.G., Liu, Y., Wongchenko, M., Yang, Y., Cheung, T.K., Maile, T.M., Lau, T., Costa, M., Hegde, G.V., Jackson, E., Pitti, R., Arnott, D., Bailey, C., Bellon, S., Cummings, R.T., Albrecht, B.K., Harmange, J.C., Kiefer, J.R., Trojer, P., Classon, M. Nat.Chem.Biol.