CATH Classification

Domain Context

CATH Clusters

Superfamily NAD(P)-binding Rossmann-like Domain
Functional Family S-(hydroxymethyl)glutathione dehydrogenase

Enzyme Information

1.1.1.1
Alcohol dehydrogenase.
based on mapping to UniProt P00327
(1) A primary alcohol + NAD(+) = an aldehyde + NADH. (2) A secondary alcohol + NAD(+) = a ketone + NADH.
-!- Acts on primary or secondary alcohols or hemi-acetals with very broad specificity; however the enzyme oxidizes methanol much more poorly than ethanol. -!- The animal, but not the yeast, enzyme acts also on cyclic secondary alcohols.

UniProtKB Entries (1)

P00327
ADH1E_HORSE
Equus caballus
Alcohol dehydrogenase E chain

PDB Structure

PDB 5CDT
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Contribution of Buried Distal Amino Acid Residues in Horse Liver Alcohol Dehydrogenase to Structure and Catalysis.
Shanmuganatham, K.K., Wallace, R.S., Lee, A.T., Plapp, B.V.
Protein Sci.