CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.10 | Roll |
|
3.10.330 | Vcp-like ATPase; Chain A, domain 2 |
|
3.10.330.20 |
Domain Context
CATH Clusters
| Superfamily | 3.10.330.20 |
| Functional Family | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A |
Enzyme Information
| 2.1.1.- |
Methyltransferases.
based on mapping to UniProt Q96FX7
|
| 2.1.1.220 |
tRNA (adenine(58)-N(1))-methyltransferase.
based on mapping to UniProt Q96FX7
S-adenosyl-L-methionine + adenine(58) in tRNA = S-adenosyl-L-homocysteine + N(1)-methyladenine(58) in tRNA.
-!- The enzyme specifically methylates adenine(58) in tRNA. -!- The methylation of A(58) is critical for maintaining the stability of initiator tRNA(Met) in yeast. -!- Formerly EC 2.1.1.36.
|
UniProtKB Entries (1)
| Q96FX7 |
TRM61_HUMAN
Homo sapiens
TRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A
|
PDB Structure
| PDB | 5CCX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal Structure of the Human tRNA m(1)A58 Methyltransferase-tRNA3(Lys) Complex: Refolding of Substrate tRNA Allows Access to the Methylation Target.
J.Mol.Biol.
|
