1 keywords

CATH Domain 5ccmA03

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.220 Annexin V; domain 1
Homologous Superfamily 1.10.220.160  

Domain Context

CATH Clusters

Superfamily 1.10.220.160
Functional Family Histone-lysine N-methyltransferase SMYD3

Enzyme Information

2.1.1.43
Histone-lysine N-methyltransferase.
based on mapping to UniProt Q9H7B4
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

UniProtKB Entries (1)

Q9H7B4
SMYD3_HUMAN
Homo sapiens
Histone-lysine N-methyltransferase SMYD3

PDB Structure

PDB 5CCM
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor.
Mitchell, L.H., Boriack-Sjodin, P.A., Smith, S., Thomenius, M., Rioux, N., Munchhof, M., Mills, J.E., Klaus, C., Totman, J., Riera, T.V., Raimondi, A., Jacques, S.L., West, K., Foley, M., Waters, N.J., Kuntz, K.W., Wigle, T.J., Scott, M.P., Copeland, R.A., Smith, J.J., Chesworth, R.
Acs Med.Chem.Lett.