CATH Domain 5c9cA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.200	Phosphorylase Kinase; domain 1
	3.30.200.20	Phosphorylase Kinase; domain 1

Domain Context

CATH Clusters

Superfamily	Phosphorylase Kinase; domain 1
Functional Family	B-Raf proto-oncogene serine/threonine-protein kinase

Enzyme Information

2.7.11.1

Non-specific serine/threonine protein kinase.

based on mapping to UniProt P15056

ATP + a protein = ADP + a phosphoprotein.

-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

P15056

BRAF_HUMAN

Homo sapiens

Serine/threonine-protein kinase B-raf

PDB Structure

PDB	5C9C
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers. Peng, S.B., Henry, J.R., Kaufman, M.D., Lu, W.P., Smith, B.D., Vogeti, S., Rutkoski, T.J., Wise, S., Chun, L., Zhang, Y., Van Horn, R.D., Yin, T., Zhang, X., Yadav, V., Chen, S.H., Gong, X., Ma, X., Webster, Y., Buchanan, S., Mochalkin, I., Huber, L., Kays, L., Donoho, G.P., Walgren, J., McCann, D., Patel, P., Conti, I., Plowman, G.D., Starling, J.J., Flynn, D.L. Cancer Cell