CATH Domain 5c90A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.226	2-enoyl-CoA Hydratase; Chain A, domain 1
	3.90.226.10	2-enoyl-CoA Hydratase; Chain A, domain 1

Domain Context

CATH Clusters

Superfamily	2-enoyl-CoA Hydratase; Chain A, domain 1
Functional Family	ATP-dependent Clp protease proteolytic subunit

Enzyme Information

3.4.21.92

Endopeptidase Clp.

based on mapping to UniProt Q2G036

Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec, and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs).

-!- Belongs to peptidase family S14.

UniProtKB Entries (1)

Q2G036

CLPP_STAA8

Staphylococcus aureus subsp. aureus NCTC 8325

ATP-dependent Clp protease proteolytic subunit

PDB Structure

PDB	5C90
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure Ni, T., Ye, F., Liu, X., Zhang, J., Liu, H., Li, J., Zhang, Y., Sun, Y., Wang, M., Luo, C., Jiang, H., Lan, L., Gan, J., Zhang, A., Zhou, H., Yang, C.-G. Acs Chem.Biol.