CATH Domain 5c8wA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.60	Sandwich
	2.60.120	Jelly Rolls
	2.60.120.10	Jelly Rolls

Domain Context

CATH Clusters

Superfamily	Jelly Rolls
Functional Family	cGMP-dependent protein kinase

Enzyme Information

2.7.11.12

cGMP-dependent protein kinase.

based on mapping to UniProt Q13237

ATP + a protein = ADP + a phosphoprotein.

-!- cGMP is required to activate this enzyme. -!- The enzyme occurs as a dimer in higher eukaryotes. -!- The C-terminal region of each polypeptide chain contains the catalytic domain that includes the ATP and protein substrate binding sites. -!- This domain catalyzes the phosphorylation by ATP to specific serine or threonine residues in protein substrates. -!- The enzyme also has two allosteric cGMP-binding sites (sites A and B). -!- Binding of cGMP causes a conformational change that is associated with activation of the kinase. -!- Formerly EC 2.7.1.37.

UniProtKB Entries (1)

Q13237

KGP2_HUMAN

Homo sapiens

CGMP-dependent protein kinase 2

PDB Structure

PDB	5C8W
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. Campbell, J.C., Kim, J.J., Li, K.Y., Huang, G.Y., Reger, A.S., Matsuda, S., Sankaran, B., Link, T.M., Yuasa, K., Ladbury, J.E., Casteel, D.E., Kim, C. J.Biol.Chem.