CATH Domain 5c36A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.550	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
	3.90.550.10	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A

Domain Context

CATH Clusters

Superfamily	Spore Coat Polysaccharide Biosynthesis Protein SpsA; Chain A
Functional Family	Histo-blood group ABO system transferase

Enzyme Information

2.4.1.37

Fucosylgalactoside 3-alpha-galactosyltransferase.

based on mapping to UniProt P16442

UDP-alpha-D-galactose + alpha-L-fucosyl-(1->2)-D-galactosyl-R = UDP + alpha-D-galactosyl-(1->3)-(alpha-L-fucosyl-(1->2))-D-galactosyl-R.

-!- Acts on blood group substance, and can use a number of 2-fucosyl- galactosides as acceptors.

2.4.1.40

Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase.

based on mapping to UniProt P16442

UDP-N-acetyl-alpha-beta-D-galactosamine + glycoprotein-alpha-L-fucosyl- (1->2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl- (1->3)-(alpha-L-fucosyl-(1->2))-beta-D-galactose.

-!- Acts on blood group substance H. -!- Can use a number of 2-fucosyl-galactosides as acceptors.

UniProtKB Entries (1)

P16442

BGAT_HUMAN

Homo sapiens

Histo-blood group ABO system transferase

PDB Structure

PDB	5C36
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	High Resolution Structures of the Human ABO(H) Blood Group Enzymes in Complex with Donor Analogs Reveal That the Enzymes Utilize Multiple Donor Conformations to Bind Substrates in a Stepwise Manner. Gagnon, S.M., Meloncelli, P.J., Zheng, R.B., Haji-Ghassemi, O., Johal, A.R., Borisova, S.N., Lowary, T.L., Evans, S.V. J.Biol.Chem.