CATH Classification
Level | CATH Code | Description |
---|---|---|
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1 | Mainly Alpha |
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1.25 | Alpha Horseshoe |
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1.25.40 | Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat |
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1.25.40.20 | Ankyrin repeat-containing domain |
Domain Context
CATH Clusters
Superfamily | Ankyrin repeat-containing domain |
Functional Family | Poly [ADP-ribose] polymerase |
Enzyme Information
2.4.2.- |
Pentosyltransferases.
based on mapping to UniProt Q9H2K2
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2.4.2.30 |
NAD(+) ADP-ribosyltransferase.
based on mapping to UniProt Q9H2K2
NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.
-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
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UniProtKB Entries (1)
Q9H2K2 |
TNKS2_HUMAN
Homo sapiens
Poly [ADP-ribose] polymerase tankyrase-2
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PDB Structure
PDB | 5BXO |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Human Tankyrase-2 in Complex with Extended Stapled Peptide sp4n2m3
To Be Published
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