CATH Classification
Level | CATH Code | Description |
---|---|---|
2 | Mainly Beta | |
2.40 | Beta Barrel | |
2.40.10 | Thrombin, subunit H | |
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
Superfamily | Trypsin-like serine proteases |
Functional Family | Tissue-type plasminogen activator |
Enzyme Information
3.4.21.68 |
T-plasminogen activator.
based on mapping to UniProt P00750
Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.
-!- From a wide variety of mammalian tissues, especially endothelial cells. -!- Secreted as a single chain precursor which is cleaved to a two-chain form by plasmin. -!- Activity is considerably enhanced by fibrin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.21.31 and EC 3.4.99.26.
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UniProtKB Entries (1)
P00750 |
TPA_HUMAN
Homo sapiens
Tissue-type plasminogen activator
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PDB Structure
PDB | 5BRR |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal Structure of the Michaelis Complex between Tissue-type Plasminogen Activator and Plasminogen Activators Inhibitor-1
J.Biol.Chem.
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