CATH Domain 5bqhA00

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.120	Four Helix Bundle (Hemerythrin (Met), subunit A)
	1.20.120.550	Membrane associated eicosanoid/glutathione metabolism-like domain

Superfamily	Membrane associated eicosanoid/glutathione metabolism-like domain
Functional Family	Microsomal glutathione S-transferase 1

5.3.99.3

Prostaglandin-E synthase.

based on mapping to UniProt O14684

(5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate.

-!- Brings about the opening of the epidioxy bridge.

PTGES_HUMAN

Homo sapiens

Prostaglandin E synthase

PDB	5BQH
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery and Characterization of 2-Acylaminoimidazole Microsomal Prostaglandin E Synthase-1 Inhibitors. Schiffler, M.A., Antonysamy, S., Bhattachar, S.N., Campanale, K.M., Chandrasekhar, S., Condon, B., Desai, P.V., Fisher, M.J., Groshong, C., Harvey, A., Hickey, M.J., Hughes, N.E., Jones, S.A., Kim, E.J., Kuklish, S.L., Luz, J.G., Norman, B.H., Rathmell, R.E., Rizzo, J.R., Seng, T.W., Thibodeaux, S.J., Woods, T.A., York, J.S., Yu, X.P. J.Med.Chem.