CATH Domain 5botA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt P45452

UniProtKB Entries (1)

MMP13_HUMAN

Homo sapiens

Collagenase 3

PDB Structure

PDB	5BOT
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13. Taylor, S.J., Abeywardane, A., Liang, S., Muegge, I., Padyana, A.K., Xiong, Z., Hill-Drzewi, M., Farmer, B., Li, X., Collins, B., Li, J.X., Heim-Riether, A., Proudfoot, J., Zhang, Q., Goldberg, D., Zuvela-Jelaska, L., Zaher, H., Li, J., Farrow, N.A. J. Med. Chem.