CATH Domain 5ayzA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.1170	Aldehyde Oxidoreductase; domain 3
	3.90.1170.20	Quinolinate phosphoribosyl transferase, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Quinolinate phosphoribosyl transferase, N-terminal domain
Functional Family	Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Enzyme Information

2.4.2.19

Nicotinate-nucleotide diphosphorylase (carboxylating).

based on mapping to UniProt Q15274

Beta-nicotinate D-ribonucleotide + diphosphate + CO(2) = pyridine-2,3- dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate.

-!- The reaction is catalyzed in the opposite direction. -!- Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD(+) biosynthesis enzyme shared by both eukaryotes and prokaryotes.

UniProtKB Entries (1)

Q15274

NADC_HUMAN

Homo sapiens

Nicotinate-nucleotide pyrophosphorylase [carboxylating]

PDB Structure

PDB	5AYZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural Insights into the Quaternary Catalytic Mechanism of Hexameric Human Quinolinate Phosphoribosyltransferase, a Key Enzyme in de novo NAD Biosynthesis Youn, H.S., Kim, T.G., Kim, M.K., Kang, G.B., Kang, J.Y., Lee, J.G., An, J.Y., Park, K.R., Lee, Y., Im, Y.J., Lee, J.H., Eom, S.H. Sci Rep