CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.70 | Cathepsin D, subunit A; domain 1 |
|
2.40.70.10 | Acid Proteases |
Domain Context
CATH Clusters
| Superfamily | Acid Proteases |
| Functional Family |
Enzyme Information
| 3.4.23.21 |
Rhizopuspepsin.
based on mapping to UniProt P06026
Hydrolysis of proteins with broad specificity similar to that of pepsin A, preferring hydrophobic residues at P1 and P1'. Clots milk and activates trypsinogen. Does not cleave 4-Gln-|-His-5, but does cleave 10-His-|-Leu-11 and 12-Val-|-Glu-13 in B chain of insulin.
-!- From the zygomycete fungi Rhizopus chinensis and R.niveus. -!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.17, EC 3.4.23.6, EC 3.4.23.9 and EC 3.4.99.25.
|
UniProtKB Entries (1)
| P06026 |
CARP_RHICH
Rhizopus microsporus var. chinensis
Rhizopuspepsin
|
PDB Structure
| PDB | 5APR |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of complexes of rhizopuspepsin with pepstatin and other statine-containing inhibitors.
Proteins
|
