CATH Domain 5aivA02

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.1050	Glutathione S-transferase Yfyf (Class Pi); Chain A, domain 2
	1.20.1050.10

Domain Context

CATH Clusters

Superfamily	1.20.1050.10
Functional Family	Hematopoietic prostaglandin D synthase

Enzyme Information

2.5.1.18

Glutathione transferase.

based on mapping to UniProt O60760

RX + glutathione = HX + R-S-glutathione.

-!- A group of enzymes of broad specificity. -!- R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. -!- Also catalyzes the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange. -!- Formerly EC 1.8.6.1, EC 2.5.1.12, EC 2.5.1.13, EC 2.5.1.14 and EC 4.4.1.7.

5.3.99.2

Prostaglandin-D synthase.

based on mapping to UniProt O60760

(5Z,13E,15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E,15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate.

-!- Brings about the opening of the epidioxy bridge.

UniProtKB Entries (1)

O60760

HPGDS_HUMAN

Homo sapiens

Hematopoietic prostaglandin D synthase

PDB Structure

PDB	5AIV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification of Indole Inhibitors of Human Hematopoietic Prostaglandin D2 Synthase (Hh-Pgds). Edfeldt, F., Even, J., Lepisto, M., Ward, A., Petersen, J., Wissler, L., Rohman, M., Sivars, U., Svensson, K., Perry, M., Feierberg, I., Zhou, X.H., Hansson, T., Narjes, F. Bioorg.Med.Chem.Lett.