CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 5AAG
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent.
Bavetsias, V., Perez-Fuertes, Y., Mcintyre, P.J., Atrash, B., Kosmopoulou, M., O'Fee, L., Burke, R., Sun, C., Faisal, A., Bush, K., Avery, S., Henley, A., Raynaud, F.I., Linardopoulos, S., Bayliss, R., Blagg, J.
Bioorg.Med.Chem.Lett.