CATH Domain 5a90A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.710	Beta-lactamase
	3.40.710.10	DD-peptidase/beta-lactamase superfamily

Domain Context

CATH Clusters

Superfamily	DD-peptidase/beta-lactamase superfamily
Functional Family

Enzyme Information

3.5.2.6

Beta-lactamase.

based on mapping to UniProt E1ANH6

A beta-lactam + H(2)O = a substituted beta-amino acid.

-!- Zinc is only requires in class-B enzymes. -!- A group of enzymes of varying specificity hydrolyzing beta-lactams; some act more rapidly on penicillins, some more rapidly on cephalosporins. -!- Formerly EC 3.5.2.8.

UniProtKB Entries (1)

E1ANH6

BLC97_ECOLX

Escherichia coli

Beta-lactamase CTX-M-97

PDB Structure

PDB	5A90
External Links	PDBSum Proteopedia
Method	NEUTRON DIFFRACTION
Organism
Primary Citation	Exploring the Mechanism of Beta-Lactam Ring Protonation in the Class a Beta-Lactamase Acylation Mechanism Using Neutron and X-Ray Crystallography. Vandavasi, V.G., Weiss, K.L., Cooper, J.B., Erskine, P.T., Tomanicek, S.J., Ostermann, A., Schrader, T.E., Ginell, S.L., Coates, L. J.Med.Chem.