CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.40 | 3-Layer(aba) Sandwich |
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3.40.605 | Aldehyde Dehydrogenase; Chain A, domain 1 |
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3.40.605.10 | Aldehyde Dehydrogenase; Chain A, domain 1 |
Domain Context
CATH Clusters
Superfamily | Aldehyde Dehydrogenase; Chain A, domain 1 |
Functional Family | NAD/NADP-dependent betaine aldehyde dehydrogenase |
Enzyme Information
1.2.1.8 |
Betaine-aldehyde dehydrogenase.
based on mapping to UniProt P17202
Betaine aldehyde + NAD(+) + H(2)O = betaine + NADH.
-!- In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine. -!- This enzyme is involved in the second step and appears to be the same in plants, animals and bacteria. -!- In contrast, different enzymes are involved in the first reaction. -!- In plants, this reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC 1.1.99.1 or soluble EC 1.1.3.17. -!- In some bacteria, betaine is synthesized from glycine through the actions of EC 2.1.1.156 and EC 2.1.1.157.
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UniProtKB Entries (1)
P17202 |
BADH_SPIOL
Spinacia oleracea
Betaine aldehyde dehydrogenase, chloroplastic
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PDB Structure
PDB | 5A2D |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Reversible, Partial Inactivation of Plant Betaine Aldehyde Dehydrogenase by Betaine Aldehyde: Mechanism and Possible Physiological Implications.
Biochem.J.
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