CATH Domain 4zzyA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.142	Poly(ADP-ribose) Polymerase; domain 1
	1.20.142.10	Poly(ADP-ribose) polymerase, regulatory domain

Domain Context

CATH Clusters

Superfamily	Poly(ADP-ribose) polymerase, regulatory domain
Functional Family	Poly [ADP-ribose] polymerase

Enzyme Information

2.4.2.-

Pentosyltransferases.

based on mapping to UniProt Q9UGN5

2.4.2.30

NAD(+) ADP-ribosyltransferase.

based on mapping to UniProt Q9UGN5

NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D- ribosyl)(n+1)-acceptor.

-!- The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxy group on a histone or the enzyme itself, and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.

UniProtKB Entries (1)

Q9UGN5

PARP2_HUMAN

Homo sapiens

Poly [ADP-ribose] polymerase 2

PDB Structure

PDB	4ZZY
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of 2-[1-(4,4-Difluorocyclohexyl)Piperidin-4-Yl]-6-Fluoro-3-Oxo-2,3-Dihydro-1H-Isoindole-4-Carboxamide (Nms-P118): A Potent, Orally Available and Highly Selective Parp- 1 Inhibitor for Cancer Therapy. Papeo, G.M.E., Posteri, H., Borghi, D., Busel, A.A., Caprera, F., Casale, E., Ciomei, M., Cirla, A., Corti, E., D'Anello, M., Fasolini, M., Forte, B., Galvani, A., Isacchi, A., Khvat, A., Krasavin, M.Y., Lupi, R., Orsini, P., Perego, R., Pesenti, E., Pezzetta, D., Rainoldi, S., Riccardi-Sirtori, F., Scolaro, A., Sola, F., Zuccotto, F., Felder, E.R., Donati, D., Montagnoli, A. J.Med.Chem.