CATH Domain 4zviA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.230	Ribosomal Protein S5; domain 2
	3.30.230.10

Domain Context

CATH Clusters

Superfamily	3.30.230.10
Functional Family	DNA gyrase subunit B

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt P0AES7

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P0AES7

GYRB_ECO57

Escherichia coli O157:H7

DNA gyrase subunit B

PDB Structure

PDB	4ZVI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	N-Phenyl-4,5-dibromopyrrolamides and N-Phenylindolamides as ATP Competitive DNA Gyrase B Inhibitors: Design, Synthesis, and Evaluation. Zidar, N., Macut, H., Tomasic, T., Brvar, M., Montalvao, S., Tammela, P., Solmajer, T., Peterlin Masic, L., Ilas, J., Kikelj, D. J.Med.Chem.