CATH Classification
Domain Context
CATH Clusters
| Superfamily | Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain |
| Functional Family | Anthranilate phosphoribosyltransferase |
Enzyme Information
| 2.4.2.18 |
Anthranilate phosphoribosyltransferase.
based on mapping to UniProt A5U4M0
N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.
-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).
|
UniProtKB Entries (1)
| A5U4M0 |
TRPD_MYCTA
Mycobacterium tuberculosis H37Ra
Anthranilate phosphoribosyltransferase
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PDB Structure
| PDB | 4ZTV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis.
To be Published
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