CATH Domain 4ztvA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.20	Up-down Bundle
	1.20.970	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain A, domain 3
	1.20.970.10	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C

Domain Context

CATH Clusters

Superfamily	Transferase, Pyrimidine Nucleoside Phosphorylase; Chain C
Functional Family	Anthranilate phosphoribosyltransferase

Enzyme Information

2.4.2.18

Anthranilate phosphoribosyltransferase.

based on mapping to UniProt A5U4M0

N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-alpha-D-ribose 1-diphosphate.

-!- In some organisms, this enzyme is part of a multifunctional protein together with one or more components of the system for biosynthesis of tryptophan (EC 4.1.1.48, EC 4.1.3.27, EC 4.2.1.20 and EC 5.3.1.24).

UniProtKB Entries (1)

A5U4M0

TRPD_MYCTA

Mycobacterium tuberculosis H37Ra

Anthranilate phosphoribosyltransferase

PDB Structure

PDB	4ZTV
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Bioactive non-anthranilate-like fragment-like inhibitor provides alternative starting point for inhibitor design against anthranilate phosphoribosyl transferase from Mycobacterium tuberculosis. Evans, G.L., Bulloch, E.M.M., Eom, J., Castell, A., Short, F.L., Baker, E.N., Lott, J.S. To be Published