CATH Classification

Domain Context

CATH Clusters

Superfamily Transferase(Phosphotransferase) domain 1
Functional Family Aurora kinase A

Enzyme Information

2.7.11.1
Non-specific serine/threonine protein kinase.
based on mapping to UniProt O14965
ATP + a protein = ADP + a phosphoprotein.
-!- This is a heterogeneous group of serine/threonine protein kinases that do not have an activating compound and are either non-specific or their specificity has not been analyzed to date. -!- Formerly EC 2.7.1.37 and EC 2.7.1.70.

UniProtKB Entries (1)

O14965
AURKA_HUMAN
Homo sapiens
Aurora kinase A

PDB Structure

PDB 4ZTS
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Discovery of a Selective Aurora A Kinase Inhibitor by Virtual Screening.
Kilchmann, F., Marcaida, M.J., Kotak, S., Schick, T., Boss, S.D., Awale, M., Gonczy, P., Reymond, J.L.
J.Med.Chem.