CATH Domain 4zswA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.640	Aspartate Aminotransferase; domain 2
	3.40.640.10	Type I PLP-dependent aspartate aminotransferase-like (Major domain)

Domain Context

CATH Clusters

Superfamily	Type I PLP-dependent aspartate aminotransferase-like (Major domain)
Functional Family

Enzyme Information

2.6.1.22

(S)-3-amino-2-methylpropionate transaminase.

based on mapping to UniProt P80147

(S)-3-amino-2-methylpropanoate + 2-oxoglutarate = 2-methyl-3- oxopropanoate + L-glutamate.

-!- Also acts on beta-alanine and other omega-amino acids having carbon chains between 2 and 5. -!- The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization, so that this enzyme, together with EC 2.6.1.40, provide a route for interconversion of the enantiomers of 3-amino-2-methylpropanoate.

2.6.1.19

4-aminobutyrate--2-oxoglutarate transaminase.

based on mapping to UniProt P80147

4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate.

-!- Some preparations also act on beta-alanine, 5-aminopentanoate and (R,S)-3-amino-2-methylpropanoate.

UniProtKB Entries (1)

P80147

GABT_PIG

Sus scrofa

4-aminobutyrate aminotransferase, mitochondrial

PDB Structure

PDB	4ZSW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Mechanism of Inactivation of GABA Aminotransferase by (E)- and (Z)-(1S,3S)-3-Amino-4-fluoromethylenyl-1-cyclopentanoic Acid. Lee, H., Le, H.V., Wu, R., Doud, E., Sanishvili, R., Kellie, J.F., Compton, P.D., Pachaiyappan, B., Liu, D., Kelleher, N.L., Silverman, R.B. Acs Chem.Biol.