CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.390 | Collagenase (Catalytic Domain) |
|
3.40.390.10 | Collagenase (Catalytic Domain) |
Domain Context
CATH Clusters
| Superfamily | Collagenase (Catalytic Domain) |
| Functional Family | endothelin-converting enzyme 1 isoform X1 |
Enzyme Information
| 3.4.24.11 |
Neprilysin.
based on mapping to UniProt P08049
Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'.
-!- A membrane-bound glycoprotein widely distributed in animal tissues. -!- Inhibited by phosphoramidon and thiorphan. -!- Belongs to peptidase family M13.
|
UniProtKB Entries (1)
| P08049 |
NEP_RABIT
Oryctolagus cuniculus
Neprilysin
|
PDB Structure
| PDB | 4ZR5 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of soluble rabbit neprilysin complexed with phosphoramidon or thiorphan.
Acta Crystallogr.,Sect.F
|
