CATH Classification
Level | CATH Code | Description |
---|---|---|
1 | Mainly Alpha | |
1.10 | Orthogonal Bundle | |
1.10.150 | DNA polymerase; domain 1 | |
1.10.150.20 | 5' to 3' exonuclease, C-terminal subdomain |
Domain Context
CATH Clusters
Superfamily | 5' to 3' exonuclease, C-terminal subdomain |
Functional Family | DNA-directed RNA polymerase subunit alpha |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P0A7Z4
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
P0A7Z4 |
RPOA_ECOLI
Escherichia coli K-12
DNA-directed RNA polymerase subunit alpha
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PDB Structure
PDB | 4ZH4 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural Basis of Transcription Inhibition by CBR Hydroxamidines and CBR Pyrazoles.
Structure
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