CATH Domain 4zcwA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.390	Enolase-like; domain 1
	3.30.390.10	Enolase-like, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Enolase-like, N-terminal domain
Functional Family	Enolase

Enzyme Information

4.2.1.11

Phosphopyruvate hydratase.

based on mapping to UniProt P09104

2-phospho-D-glycerate = phosphoenolpyruvate + H(2)O.

-!- Also acts on 3-phospho-D-erythronate.

UniProtKB Entries (1)

ENOG_HUMAN

Homo sapiens

Gamma-enolase

PDB Structure

PDB	4ZCW
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	SF2312 is a natural phosphonate inhibitor of enolase. Leonard, P.G., Satani, N., Maxwell, D., Lin, Y.H., Hammoudi, N., Peng, Z., Pisaneschi, F., Link, T.M., Lee, G.R., Sun, D., Prasad, B.A., Di Francesco, M.E., Czako, B., Asara, J.M., Wang, Y.A., Bornmann, W., DePinho, R.A., Muller, F.L. Nat.Chem.Biol.