CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.660 | Polyamine Oxidase; Chain A, domain 2 |
|
3.90.660.10 |
Domain Context
CATH Clusters
| Superfamily | 3.90.660.10 |
| Functional Family | Renalase |
Enzyme Information
| 1.6.3.5 |
Renalase.
based on mapping to UniProt Q48MT7
(1) 1,2-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2). (2) 1,6-dihydro-beta-NAD(P) + H(+) + O(2) = beta-NAD(P)(+) + H(2)O(2).
-!- Renalase, previously thought to be a hormone, is a flavoprotein secreted into the blood by the kidney that oxidizes the 1,2-dihydro- and 1,6-dihydro- isomeric forms of beta-NAD(P)H back to beta- NAD(P)(+). -!- These isomeric forms, generated by nonspecific reduction of beta- NAD(P)(+) or by tautomerization of beta-NAD(P)H, are potent inhibitors of primary metabolism dehydrogenases and pose a threat to normal respiration.
|
UniProtKB Entries (1)
| Q48MT7 |
RNLS_PSE14
Pseudomonas savastanoi pv. phaseolicola 1448A
Renalase
|
PDB Structure
| PDB | 4ZCD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Bacterial Renalase: Structure and Kinetics of an Enzyme with 2- and 6-Dihydro-beta-NAD(P) Oxidase Activity from Pseudomonas phaseolicola.
Biochemistry
|
